Specialized Chromatography

Advanced Separation Solutions for Complex Challenges

High-value analytical platforms for biopharmaceutical, polymer science, materials research, and advanced R&D

Advanced Solutions Beyond Conventional Chromatography

For complex, high-value analytical challenges, Chemplanet offers specialized chromatography platforms designed for advanced molecular separation, characterization, and purification. These technologies address analytical requirements that extend beyond conventional LC and GC methods, delivering greater selectivity, efficiency, and insight.

Our specialized chromatography solutions are widely used in biopharmaceutical research, polymer science, advanced materials analysis, and high-end R&D laboratories, supported by expert application knowledge and long-term service.

SFC

Supercritical Fluid Chromatography

Fast, efficient separations with reduced solvent consumption

Green Chemistry Chiral Separations

SEC

Size Exclusion Chromatography

Molecular weight and polymer characterization

Polymer Analysis Macromolecules

Affinity

Affinity Chromatography

Highly selective bio-separations

Protein Purification Biopharma
Fast, Efficient & Sustainable Separations

Supercritical Fluid Chromatography (SFC)

Combines the advantages of gas and liquid chromatography using supercritical CO₂

Supercritical Fluid Chromatography (SFC) combines the advantages of gas and liquid chromatography, using supercritical CO₂ as the primary mobile phase to achieve rapid, high-resolution separations with significantly reduced solvent consumption.

System Capabilities

Fast Analysis Times

High throughput with rapid separation cycles

Excellent Efficiency

Superior resolution for chiral and non-polar compounds

Reduced Solvent Use

Up to 80% less organic solvent consumption

Scalable Workflows

Seamless scaling from analytical to preparative

System Types & Platform Classes

Analytical SFC Systems

Designed for method development and routine analysis with high reproducibility and precise pressure control.

  • Method development platform
  • Precise pressure control
  • Routine analysis ready

Preparative SFC Systems

Suitable for compound purification and scale-up with integrated fraction collection capabilities.

  • Compound purification
  • Scale-up capabilities
  • Fraction collection

Hybrid LC-SFC Platforms

Seamless switching between LC and SFC modes for flexible multi-technique laboratories.

  • Dual-mode operation
  • Flexible workflows
  • Multi-technique lab
Most Versatile

Key Applications

01

Chiral Separations

Pharmaceutical development and enantiomer analysis

02

Impurity Profiling

Metabolite analysis and impurity characterization

03

Natural Products

Fine chemical and natural product analysis

04

Green Chemistry

Sustainability-driven laboratory workflows

Molecular Weight & Polymer Characterization

Size Exclusion Chromatography (SEC)

Also known as Gel Permeation Chromatography (GPC) for macromolecular analysis

Size Exclusion Chromatography (SEC), also known as Gel Permeation Chromatography (GPC), separates molecules based on hydrodynamic volume, making it a critical technique for polymer and macromolecular analysis.

System Capabilities

Accurate MW Analysis

Precise molecular weight distribution determination

Mw/Mn < 1.05 Polydispersity

High Reproducibility

Robust methods with excellent repeatability

<2% RSD Precision

Dual Mobile Phases

Compatible with organic and aqueous systems

THF • DMF • H₂O Solvents

Multi-Detector Integration

Comprehensive molecular characterization

RI • LS • Visc Detectors

System Types & Platform Classes

Standard

SEC/GPC Systems

Suitable for routine polymer analysis with refractive index and UV detection.

  • Routine polymer analysis
  • RI and UV detection
  • Calibration standards included
  • Temperature control
Advanced

Multi-Detector SEC Platforms

Integration with light scattering and viscometry for absolute molecular weight determination.

  • Light scattering detection
  • Viscometry integration
  • Absolute MW determination
  • Triple detection
Expert Level
Specialized

High-Temperature SEC Systems

Designed for challenging polymers with stable operation using high-boiling solvents.

  • High temp operation
  • Challenging polymers
  • High-boiling solvents
  • Industrial applications

Applications

Polymer Molecular Weight Distribution

Comprehensive analysis of synthetic polymers, plastics, and rubber materials for research, development, and quality control applications.

Synthetic Polymers Plastics Rubber Copolymers
Highly Selective Bio-Separations

Affinity Chromatography

Targeted separation of biomolecules using specific molecular interactions

Technology Principle

Affinity Chromatography enables highly selective separation of biomolecules using specific interactions between a target molecule and an immobilized ligand. This provides exceptional purity and recovery for sensitive biological samples.

Target-Specific
High Purity
Sensitive Samples

System Capabilities

Exceptional Selectivity

Target-specific separation with minimal non-specific binding

High Recovery

Maximized yield of sensitive biomolecules

Flexible Conditions

Compatible with native and denaturing buffers

Scalable Workflows

Seamless scaling from analytical to process scale

Platform Classes & Systems

Analytical Affinity LC Systems

Research

Used for biomolecule characterization, binding studies, and method development.

Binding Studies
Method Development
Characterization

Preparative & Process-Scale Systems

Production

Designed for protein purification and bioprocess workflows at scale.

Scale-up Purification
Bioprocess Integration
Multi-cycle Operation

Bio-Inert Platforms

Sensitive

Metal-free flow paths and biocompatible materials to protect sensitive samples.

Metal-Free
Biocompatible
Sample Protection

Key Applications

Protein & Enzyme Purification

Core Application

High-purity isolation of recombinant proteins, enzymes, and therapeutic proteins using specific affinity ligands.

Antibody Workflows

mAb Focus

Monoclonal antibody purification and characterization for biopharmaceutical development and production.

Interaction Studies

Research

Ligand-binding studies, kinetic analysis, and molecular interaction characterization.

Biopharmaceutical R&D

Industry

Drug development, process optimization, and quality control in biopharmaceutical manufacturing.

End-to-End Expertise & Comprehensive Support

Complete lifecycle support for specialized chromatography technologies

Detector Compatibility & System Integration

UV & DAD Detectors

UV-Vis and Diode Array Detection for comprehensive analysis

Refractive Index (RI)

Universal detection for polymers and macromolecules

Light Scattering

Multi-angle light scattering (MALS) for absolute MW

Mass Spectrometry

LC-MS and GC-MS interfaces for comprehensive analysis

Chemplanet Support Services

01

Application Assessment

Feasibility studies and optimal system configuration

02

Method Development

Custom method optimization for your specific needs

03

Installation & Commissioning

Complete system setup with full training

04

Validation Support

IQ/OQ/PQ documentation for regulated environments

05

Long-term Service

Preventive maintenance and service contracts

Why Choose Chemplanet for Specialized Chromatography?

Advanced Expertise

Deep knowledge in niche chromatography techniques for complex analytical challenges

Regulatory Alignment

Solutions designed for high-end research and regulated workflow compliance

Regional Strength

Strong technical support network across South Africa and SADC region

Trusted Partnership

Reliable partner for complex analytical challenges with proven track record

Long-term Support

Comprehensive service, maintenance, and application support throughout instrument lifecycle